Polynucleotides

Polynucleotides are purified DNA fragments used in regenerative aesthetic medicine to support skin repair and tissue quality. Once injected, they help create a favourable environment for fibroblast activity. Fibroblasts are important cells within the skin that produce collagen and elastin, which contribute to firmness, elasticity and structure.

Polynucleotides also attract and retain water, helping to improve hydration, skin texture and overall radiance. They have antioxidant and anti-inflammatory properties, meaning they can help support skin affected by oxidative stress, sensitivity, inflammation or early ageing.

Unlike dermal fillers, polynucleotides are not used to add volume or reshape the face. Instead, they work gradually by supporting the skin’s own repair processes. This makes them particularly useful for delicate or crepey areas, such as the under-eyes, neck, décolletage and hands, where the goal is skin quality rather than structural volume.

Ameela polynucleotides are derived from wild salmon and are purified to a high standard. The range includes targeted formulations with different concentrations, allowing treatment to be tailored to the area, skin thickness and clinical concern.

Polynucleotides can also be combined with other treatments, including exosomes, microneedling, radiofrequency microneedling, platelet rich plasma, anti-wrinkle injections and dermal fillers, depending on the treatment plan.

You will undergo a thorough consultation in clinic in order to determine whether the treatment is suitable and beneficial for you.

Polynucleotides can be administered either as a series of micro-injections using a fine needle (mesotherapy technique), through use of a fine cannula or through a combination of the 2 techniques.

There is a little bit of short lived associated stinging but numbing cream can be used to alleviate the discomfort.

Patients can typically resume normal activities immediately.

You will be aware of small little bumps under the skin that resemble mosquito bites and in undereye treatments there may be some puffiness and bruising for 3-5 days.

Results are gradual and progressive, with optimal skin improvement observed after the second session.​

It is recommended that you have 2-3 sessions at 4-6 weeks apart for best results.

Aftercare is an important part of achieving the best results.

• Avoid exercise for 24 hours after treatment.
• Avoid excessive heat for 24 hours after treatment.
• Avoid rubbing or massaging the area for 24 hours after treatment.
• Avoid use of make-up over the puncture sites for a minimum of 6 hours; ideally wait until the following day.
• Mild redness or small bumps may occur and settle within 1-2 days.
• Under-eye swelling and bruising may occur and last 3-5 days.

You will receive tailored aftercare advice during your consultation.